ABSTRACT
Due to its multisystem involvement, IgG4 -related disease should be considered in the differential diagnosis of medical conditions such as lymphadenopathies, aortitis, serositis and retroperitoneal fibrosis. It shares features with other entities historically described as "great mimickers" such as syphilis, tuberculosis, sarcoidosis, and systemic lupus erythematosus. We report a 40 year-old male with recurrent effusive - constrictive pericarditis, lymphadenopathy and aortitis. The study revealed an inactive tuberculosis with negative cultures for acid fast bacilli. The patient had high serum levels of IgG4 and a mediastinal lymph node biopsy was consistent with IgG4 -related disease. The patient was treated with prednisone 40 mg/day with an excellent response.
Subject(s)
Adult , Humans , Male , Aortitis/diagnosis , Immunoglobulin G/blood , Lymphatic Diseases/diagnosis , Aortitis/blood , Biopsy , Diagnosis, Differential , Lymphatic Diseases/blood , Tomography, X-Ray ComputedABSTRACT
Associations of some hematological and lymphatic diseases with sex and ABO and Rh blood groups were studied in 2579 patients, compared with a control group of 126332 individuals, by the use of clinical as well as laboratory findings, in Tehran. Highly significant increase of male/female ratio is shown in acute myelogenous leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, aplastic anaemia and paroxismal nocturnal haematuria. Idiopathic thrombocy'topoenic purpura shows a decrease of this ration. In chronic myelocytic leukemia and acute lymphocytic leukemia, group 0 has the highest incidence, followed by groups A and B, and group AB has the lowest incidence. Between various diseases, the highest frequency of blood group A was went observed in Hodgkin's disease, and the lowest in NHL. Group B had highest frequency within PNH patients and the lowest in NHL. Group 0 had the highest In AML patients there is a significant decrease of Rh negative patient 17.15%]. The highest incidence of Rh negative was among the SA patients [18.18%] and the lowest in MM [3.70%]
Subject(s)
Humans , Sex Ratio , ABO Blood-Group System , Rh-Hr Blood-Group System , Hematologic Diseases/blood , Lymphatic Diseases/bloodSubject(s)
Humans , Male , Female , Lymphatic Diseases/blood , Lymph Nodes/pathology , Bone Marrow/pathology , Lymphadenitis/blood , SerologyABSTRACT
Se estudia la história clínica del primer caso de Síndrome Hemofagocítico Benigno (SHB) diagnóstico en Panamá. La paciente presentó un cuadro clínico caracterizado por fiebre, anemia, linfadenitis cervical, hepatomegalia, linfocitosis e histofagocitosis de células rojas y linfocitos de neutrófilos y plaquetas. La remisión de la fiebre se produjó setenta días después del comienzo de la enfermedad. No obstante que no se pudo demostrar serológicamente que el síndrome hemofagocítico era debido a la Toxoplasmosis de tipo agudo se le prescribió Sulfadiazina y Pirimetamina, por quince días (a los 37 días de hospitalización) y Clindamicina, por 10 días (desde los 53 días) en forma consecutiva. La remisión se produjo 70 días después del comienzo de la fiebre. Un segundo examen serológico por toxoplasma (IFA) demostró que la reacción fue nuevamente de 1:2048, nueve meses después de la anterior